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COMPLETED
NCT06165198
NA

Individualized Neuromodulation for the Core Clinical Features of Drug Addiction

Sponsor: Shanghai Mental Health Center

View on ClinicalTrials.gov

Summary

Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop tACS based on brain states, assessing dosage, neurologic and behavioral effects, while comparing its efficacy with traditional open-loop tACS methods.

Official title: Individualized Neuromodulation Intervention Techniques for the Core Clinical Features of Drug Addiction

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

9

Start Date

2023-09-25

Completion Date

2024-09-25

Last Updated

2026-08-14

Healthy Volunteers

No

Interventions

DEVICE

Closed-loop tACS stimulation based on addiction-induced states

We will conduct a crossover study of closed-loop tACS interventions among participants with methamphetamine use disorder. Participants will receive three single-session EEG-triggered closed-loop tACS interventions at frequencies previously reported to improve cognitive control, administered in a counterbalanced within-subject order. After the optimal frequency is identified based on the predefined neurobehavioral outcomes, participants will receive two additional conditions at the same frequency: random-time stimulation and open-loop continuous stimulation. All five stimulation sessions will be separated by a 5-day interval.

Locations (1)

Shanghai Mental Health Center

Shanghai, Shanghai Municipality, China