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Individualized Neuromodulation for the Core Clinical Features of Drug Addiction
Sponsor: Shanghai Mental Health Center
Summary
Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop tACS based on brain states, assessing dosage, neurologic and behavioral effects, while comparing its efficacy with traditional open-loop tACS methods.
Official title: Individualized Neuromodulation Intervention Techniques for the Core Clinical Features of Drug Addiction
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
9
Start Date
2023-09-25
Completion Date
2024-09-25
Last Updated
2026-08-14
Healthy Volunteers
No
Conditions
Interventions
Closed-loop tACS stimulation based on addiction-induced states
We will conduct a crossover study of closed-loop tACS interventions among participants with methamphetamine use disorder. Participants will receive three single-session EEG-triggered closed-loop tACS interventions at frequencies previously reported to improve cognitive control, administered in a counterbalanced within-subject order. After the optimal frequency is identified based on the predefined neurobehavioral outcomes, participants will receive two additional conditions at the same frequency: random-time stimulation and open-loop continuous stimulation. All five stimulation sessions will be separated by a 5-day interval.
Locations (1)
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China