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A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension
Sponsor: AstraZeneca
Summary
This is a Phase III, multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the safety, tolerability and the effect of 2 mg Baxdrostat vs. placebo, administered QD orally, on the reduction of SBP, measured by average 24-hour ABPM in 212 participants with rHTN (defined as seated SBP ≥ 140 mmHg at Screening and mean ambulatory SBP ≥ 130 mmHg at baseline, despite a stable regimen of ≥ 3 antihypertensive agents, one of which is a diuretic).
Official title: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
218
Start Date
2024-03-01
Completion Date
2025-08-17
Last Updated
2026-08-06
Healthy Volunteers
No
Conditions
Interventions
Baxdrostat
Baxdrostat tablet administered orally, once daily (QD). Unit dose strength: • 2 mg per tablet.
Placebo
Placebo tablet matching baxdrostat, administered orally, once daily (QD).
Locations (102)
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Surprise, Arizona, United States
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Hollywood, Florida, United States
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Lake Worth, Florida, United States
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Port Charlotte, Florida, United States
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Fort Wayne, Indiana, United States
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Lexington, Kentucky, United States
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The Bronx, New York, United States
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Greenville, North Carolina, United States
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Jacksonville, North Carolina, United States
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Kinston, North Carolina, United States
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New Bern, North Carolina, United States
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Wilmington, North Carolina, United States
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Langhorne, Pennsylvania, United States
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Brownsville, Texas, United States
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Corpus Christi, Texas, United States
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Lampasas, Texas, United States
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CABA, Argentina
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CABA, Argentina
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Capital Federal, Argentina
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Córdoba, Argentina
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Lanús Este, Argentina
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Rosario, Argentina
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San Miguel de Tucumán, Argentina
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San Vicente, Argentina
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Clayton, Australia
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Perth, Australia
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Ghent, Belgium
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Edmonton, Alberta, Canada
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North Vancouver, British Columbia, Canada
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Cambridge, Ontario, Canada
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Toronto, Ontario, Canada
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Waterloo, Ontario, Canada
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Chicoutimi, Quebec, Canada
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Terrebonne, Quebec, Canada
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Benešov, Czechia
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Brandýs nad Labem, Czechia
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Broumov, Czechia
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Louny, Czechia
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Bad Homburg, Germany
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Berlin, Germany
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Frankfurt, Germany
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Kaiserslautern, Germany
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Athens, Greece
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Attica, Greece
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Thessaloniki, Greece
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Budapest, Hungary
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Budapest, Hungary
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Kalocsa, Hungary
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Nyíregyháza, Hungary
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Pécs, Hungary
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Kota Bharu, Malaysia
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Muar town, Malaysia
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Sarawak Miri, Malaysia
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Angeles City, Philippines
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Iloilo City, Philippines
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Bialystok, Poland
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Gdansk, Poland
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Krakow, Poland
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Lodz, Poland
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Poznan, Poland
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Warsaw, Poland
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Riyadh, Saudi Arabia
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Riyadh, Saudi Arabia
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Brezno, Slovakia
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Košice, Slovakia
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Svidník, Slovakia
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Cape Town, South Africa
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Durban, South Africa
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Barcelona, Spain
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Barcelona, Spain
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Madrid, Spain
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Madrid, Spain
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Santa Coloma de Gramenet, Spain
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Terrassa (Barcelona), Spain
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Valencia, Spain
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New Taipei City, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Bangkok, Thailand
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Bangkok, Thailand
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Bangkok, Thailand
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Chiang Mai, Thailand
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Khon Kaen, Thailand
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Adana, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Kahramanmaraş, Turkey (Türkiye)
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Kayseri, Turkey (Türkiye)
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Odunpazari, Turkey (Türkiye)
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Corby, United Kingdom
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London, United Kingdom
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London, United Kingdom
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Prescot, United Kingdom
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Swindon, United Kingdom
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Thetford, United Kingdom
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Weston-super-Mare, United Kingdom
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Yate, United Kingdom
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Hanoi, Vietnam