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Does Fluorescence With or Without Indocyanine Green Improve Parathyroid Identification and Preservation
Sponsor: University of Alabama at Birmingham
Summary
The aim of this study is to determine if fluorescence with or without indocyanine green can facilitate safe and accurate thyroid and parathyroid surgery.
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
417
Start Date
2024-04-11
Completion Date
2026-05-01
Last Updated
2025-05-06
Healthy Volunteers
No
Conditions
Interventions
Indocyanine green
ICG Administration: All enrolled patients with scheduled thyroidectomy or parathyroidectomy will receive a standard cervical incision that afford access to either side of neck. Following sufficient exposure of thyroid, 25 mg of indocyanine green (ICG), reconstituted in 10 ml of sterile water, will be administered intravenously. A dosage of 1 ml of this solution will be injected into a peripheral IV line, followed by a 5 ml flush of normal saline to ensure the propagation of the dye within the vascular compartment.
SPY Portable Handheld Imaging
Fluorescent Imaging: Approximately 30 seconds post-administration, the parathyroid glands are expected to exhibit fluorescence under near-infrared imaging. The emitted fluorescence is anticipated to persist for approximately 20 minutes, allowing ample time for intraoperative evaluation of parathyroid viability and perfusion
Locations (1)
UAB Callahan Eye
Birmingham, Alabama, United States