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E-cigarette Harm Reduction Among PLWHA in South Africa
Sponsor: NYU Langone Health
Summary
The purpose of this pilot randomized controlled trial study aims to address the unmet need for feasible and efficacious strategies for reducing combustible cigarette (CC) use among people living with HIV/AIDS (PLWHA) in South Africa, which has the potential to significantly improve the health and long-term survival of PLWHA CC smokers. Using the proposed intervention, based on the Information-Motivation-Behavioral Skills (IMB), and a simultaneous embedded mixed methods approach, the investigators will evaluate a telehealth program targeting CC harm reduction, comparing E-cigarettes (EC) to nicotine replacement therapy (NRT) that is enhanced by integrating ecological momentary intervention (EMI) texting. As such, this proposal will significantly build research capacity in South Africa to conduct telehealth tobacco treatment interventions using innovative EMI approaches enhancing participants' engagement, as well as state-of-the art evaluation approaches.
Official title: Evaluating Smoking Cessation and Harm Reduction Approaches Among People Living With HIV/AIDS in South Africa
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
106
Start Date
2025-04-15
Completion Date
2026-02-27
Last Updated
2025-11-03
Healthy Volunteers
No
Conditions
Interventions
Nicotine Replacement Therapy (NRT)
NRT (daily patches and lozenges). NRT strength will be according to the established dosing guidelines for tobacco treatment. NRT is the standard of care in tobacco treatment and helped reduce CPD in prior trials
E-Cigarette (EC)
EC with single-use pods. Nicotine - 48 mg/ ml (4.8% nicotine) concentration.
Counseling
Each participant will receive up to 5-motivational counseling sessions. The first session will also include orientation of EMA/EMI texting.
Locations (1)
South African Medical Research Council (SAMRC)
Cape Town, South Africa