Clinical Research Directory

Inclusion Criteria: * • Men and women aged ≥18 and \<55 years * BMI ≥18 and ≤30 kg/m2 * Normal (or clinically irrelevant abnormal) findings in medical history and physical examination * Women with child-bearing potential: use of effective contraception * Laboratory parameters within the given reference range (or abnormal findings which are irrelevant for study purposes in the Investigator's opinion) Exclusion Criteria: * Known or suspected allergy to lipopolysaccharide, imiquimod, or sticking plasters * Only Part 0c: Known or suspected allergy to local anesthetics * History of severe allergic or anaphylactic reactions to any medication • Blood donation within the last 4 weeks before the study * Treatment with an investigational drug within three weeks before the study * Smoking of more than 5 cigarettes per day * Regular use of medication or abuse of alcohol * Use of any medication within one week before the study * Symptoms of a clinically relevant illness in the 3 months before the study * Liver or kidney dysfunction * Pregnancy * History of autoimmune diseases (especially psoriasis) * Other objections to participating in the study in the opinion of the Investigator