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ACTIVE NOT RECRUITING
NCT06171802
PHASE4

EMPagliflozin After Aortic Valve Replacement

Sponsor: Rigshospitalet, Denmark

View on ClinicalTrials.gov

Summary

The study is a randomized, placebo-controlled, and double-blinded trial in patients with aortic stenosis (AS) undergoing aortic valve replacement (AVR). After AVR, patients will be randomized 1:1 to empagliflozin (SGLT2i) or placebo to investigate whether empagliflozin is superior to placebo in reducing left ventricular mass and improve symptoms to 6 months.

Official title: EMPagliflozin After Aortic Valve Replacement - The EMPAVR Study - A Randomized Clinical Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

205

Start Date

2024-02-14

Completion Date

2026-06

Last Updated

2025-11-20

Healthy Volunteers

No

Interventions

DRUG

Empagliflozin

10 mg empagliflozin daily for six months

DRUG

Placebo

Placebo capsule once daily for six months

Locations (1)

University Hospital of Copenhagen, Rigshospitalet

Copenhagen, Denmark