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EMPagliflozin After Aortic Valve Replacement
Sponsor: Rigshospitalet, Denmark
Summary
The study is a randomized, placebo-controlled, and double-blinded trial in patients with aortic stenosis (AS) undergoing aortic valve replacement (AVR). After AVR, patients will be randomized 1:1 to empagliflozin (SGLT2i) or placebo to investigate whether empagliflozin is superior to placebo in reducing left ventricular mass and improve symptoms to 6 months.
Official title: EMPagliflozin After Aortic Valve Replacement - The EMPAVR Study - A Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
205
Start Date
2024-02-14
Completion Date
2026-06
Last Updated
2025-11-20
Healthy Volunteers
No
Conditions
Interventions
Empagliflozin
10 mg empagliflozin daily for six months
Placebo
Placebo capsule once daily for six months
Locations (1)
University Hospital of Copenhagen, Rigshospitalet
Copenhagen, Denmark