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RECRUITING
NCT06173401
PHASE3

Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases

Sponsor: Stanford University

View on ClinicalTrials.gov

Summary

The goal of this study is to determine whether fractionated Stereotactic radiosurgery (SRS) for spine metastases is associated with improved local tumor control compared to single-fraction SRS. Patients will be randomized to treatment with spine SRS using either 22 Gy in 1 fraction or 28 Gy in 2 fractions.

Official title: A Randomized Phase III TriaL Comparing SingLe- Versus Multi-Fraction Spine STereotActic Radiosurgery for Patients With Spinal Metastases (ALL-STAR)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

274

Start Date

2023-12-18

Completion Date

2028-12

Last Updated

2025-07-16

Healthy Volunteers

No

Interventions

RADIATION

Single-fraction spine SRS

Treatment Arm 1: Single-fraction spine SRS (22 Gy x 1)

RADIATION

Multi-fraction spine SRS

Treatment Arm 2: Multi-fraction spine SRS (14 Gy x 2)

Locations (1)

Stanford University School of Medicine

Palo Alto, California, United States