Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

RECRUITING

NCT06173986

PHASE1/PHASE2

Immunotherapy in Combination With Chemoradiotherapy in Unresectable Locally Advanced Esophageal Cancer

Sponsor: Shanghai Chest Hospital

View on ClinicalTrials.gov

Summary

SCR-ESCC-02 is a multicenter, phase I/II clinical study to investigate the safety and efficacy of induction immunochemotherapy followed by concurrent chemoradiotherapy with anti-PD-1 therapy in patients diagnosed with locally advanced, unresectable esophageal cancer.

Official title: A Phase I/II Multicenter Study Evaluating the Efficacy and Safety of Induction Immunochemotherapy Followed by Concurrent Immuno-Chemoradiotherapy in Unresectable Locally Advanced Esophageal Squamous Cell Cancer(SCR-ESCC-02)

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2023-01-10

Completion Date

2027-12-30

Last Updated

2023-12-18

Healthy Volunteers

Conditions

Esophageal Squamous Cell Carcinoma Unresectable Locally Advanced Esophageal Cancer

Interventions

DRUG

PD-1inhibitor

PD-1 inhibitor, Q3W, until disease progression or unacceptable toxicity or treatment reaches 1 year

DRUG

nab-paclitaxel + cisplatin

Induction phase: nab-paclitaxel + cisplatin, Q3W × 2 cycles; Concurrent ICRT phase: nab-paclitaxel + cisplatin, QW × 5 cycles

RADIATION

Radiotherapy

Primary tumor and metastatic lymph nodes, DT:45-50Gy/25fx, starting within 4 weeks following the completion of the last induction immunochemotherapy cycle

Inclusion Criteria: 1. Age between 18 and 75 years. 2. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. 3. Clinical stage meeting the criteria of T1N+M0 or T2-4aN0-3M0 based on the 8th UICC-TNM classification. 4. Ineligibility for surgical resections due to patients' unwillingness for surgery, technically unresectable disease, or being medically unfit for surgery. 5. No prior anti-tumor treatment, including surgery, radiotherapy, chemotherapy, immunotherapy, or targeted therapy. 6. Adequate hematological, pulmonary, cardiac, hepatic, renal, and thyroid function. 7. Willingness to use contraception with an adequate method throughout the study. 8. Documented informed consent. Exclusion Criteria: 1. History of malignant disease within the 5 years preceding enrollment or presence of other malignant tumors or non-squamous cell carcinoma components. 2. High risk of gastrointestinal bleeding, esophageal fistula, or esophageal perforation as determined by the investigators. 3. Weight loss exceeding 20% within the 90 days prior to the first day of drug administration. 4. Presence of long-standing unhealed wounds or fractures or undergoing major surgical resections within 60 days preceding the first day of drug administration. 5. Presence of any severe or uncontrolled coexisting diseases, including but not limited to: * Uncontrolled hypertension * History of interstitial lung disease or non-infectious pneumonia * Active hepatitis B or C, syphilis, or other active and uncontrolled infections * Cardiac insufficiency (NYHA≥2) * Renal dysfunction requiring dialysis * Active autoimmune disease * History of acquired or congenital immunodeficiency diseases 6. Occurrence of serious arterial/venous thrombotic events within 6 months prior to the first day of drug administration. 7. History of psychotropic substance abuse or inability to quit, or patients with psychotic disorders. 8. Allergy to study drugs. 9. Patients deemed unsuitable for participation due to severe comorbidities or other reasons determined by the investigators.

Locations (1)

Shanghai Chest Hospital

Shanghai, China