Clinical Research Directory

Inclusion Criteria: 1. Subjects whose clinic blood pressure measured in visit 1 corresponds to the following conditions * sitSBP \< 180 mmHg and sitDBP \< 110mg for patients receiving any BP-lowering drug within 1 month prior to Visit 1 * 140mmHg ≤ sitSBP \< 180mmHg and 60mmHg ≤ sitDBP \< 110mmHg 2. Subjects whose clinic and ambulatory blood pressure measured in visit 2 corresponds to the following conditions * 24h-ABPM: 130mmHg ≤ SBP \< 170mmHg * clinic BP: 140 mmHg ≤ sitSBP \< 180 mmHg and 60 mmHg ≤ sitDBP \< 110 mmHg Exclusion Criteria: 1. Difference between arms greater than 20 mmHg for mean sitSBP or 10mmHg for mean sitDBP at Visit 1 2. Patients who have taken more than three components of Blood pressure medication within 3 months prior to Visit 1 3. Orthostatic hypotension with symptoms within 3 months prior to visit 1 4. Secondary hypertension patient or suspected to be 5. Uncontrolled type II diabetes mellitus (HbA1c \> 9%) or type I diabetes mellitus 6. Severe heart disease or severe neurovascular disease 7. Moderate or malignant retinopathy 8. Severe renal diseases (eGFR\<30mL/min/1.73m2) 9. Severe or active hepatopathy (AST or ALT ≥ 2 times of normal range) 10. Hypokalemia or Hyperkalemia (K\<3.5mmol/L or K ≥ 5.5mmol/L) 11. Hyponatremia or Hypernatremia (Na\<135mmol/L or Na ≥ 155mmol/L) 12. History of malignancy tumor 13. History of alcohol or drug abuse 14. Positive to pregnancy test, nursing mother, intention on pregnancy 15. Considered by investigator as not appropriate to participate in the clinical study with other reason