Clinical Research Directory
Browse clinical research sites, groups, and studies.
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension
Sponsor: Vanderbilt University Medical Center
Summary
Based on existing literature and clinical trials, 2- hydroxbenzylamine (2-HOBA) has clear impact on mechanisms that much of the international field of pulmonary hypertension (PH) research agrees are central to disease progression. The investigator's preliminary data and Phase I studies demonstrate not only a clear positive impact on reducing pulmonary vascular resistances in Group I and II PH, and both cytokine and molecular biomarkers of disease, but also indicated the potential for a substantial positive effect on heart function under load stress. In this Phase II project, investigators will test the safety and efficacy of 2-HOBA in PH patients, improving the function of the right ventricle under stress in a large animal model, and effectiveness in the context of standard-of-care in mouse models and large animals, to establish the remaining data needed to proceed to commercialization.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2026-05-01
Completion Date
2027-07
Last Updated
2026-02-18
Healthy Volunteers
No
Conditions
Interventions
2-HOBA
2-HOBA supplement take three times daily for 12-weeks