Clinical Research Directory
Browse clinical research sites, groups, and studies.
Lactobreath: A Study to Diagnose Lactose Intolerance Using Breath Markers
Sponsor: ETH Zurich
Summary
Food intolerances affect many people and can cause discomfort and dietary challenges. One common cause is difficulty digesting certain carbohydrates called FODMAPs. Diagnosing food intolerance is often done by excluding and then slowly reintroducing these carbohydrates or using a hydrogen breath test, but these methods have limitations. To address these issues, this project uses the breath we exhale to find markers for lactose intolerance as a model for food intolerance diagnosis. Our aim is to identify breath markers for lactose tolerance and intolerance and link them to metabolic traits, including those found in urine. We use a real-time breath analysis method and a special sensor to measure gases in the digestive system, and we also explore genetic factors using saliva samples. This project aims to help clinicians better identify patients who should follow low FODMAP diets and provide non-invasive breath tests to predict how patients will respond to these diets. It will also advance the use of breath analysis for personalized nutrition, contributes to the broader field of food intolerance research, and has the potential to benefit millions of individuals worldwide.
Official title: Lactobreath: A Pilot Study to Diagnose Lactose Intolerance Based on the Exhaled Breath Metabolome
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2024-06-24
Completion Date
2025-12
Last Updated
2025-07-08
Healthy Volunteers
Yes
Conditions
Interventions
Lactose solution/Glucose solution
Single ingestion of a lactose/glucose solution.
Locations (1)
ETH Zurich
Zurich, Canton of Zurich, Switzerland