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RECRUITING
NCT06179004
PHASE3

Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

Sponsor: University of North Carolina, Chapel Hill

View on ClinicalTrials.gov

Summary

Orthopedic wrist procedures often cause significant postoperative pain. A supraclavicular nerve block is an effective and proven method to help reduce postoperative pain and decrease opioid use around the time of upper extremity surgery. Liposomal bupivacaine (Exparel) has been approved for use around the brachial plexus, but its analgesic efficacy has limited data. The investigators' goal is to evaluate the effectiveness of Exparel as compared to plain bupivacaine. The investigators hope to ensure the quality of pain control around the time of distal radius fracture repair and reduce the variability of care at the investigators institution by prospectively and rigorously collecting perioperative data during this study.

Official title: Randomized Controlled Trial of Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2024-04-10

Completion Date

2026-10

Last Updated

2025-10-24

Healthy Volunteers

Yes

Interventions

DRUG

Liposomal bupivacaine

133mg Liposomal bupivacaine plus 10mL 0.5% bupivacaine administered in a supraclavicular single shot perineural injection

DRUG

Bupivacaine Hydrochloride

20mL 0.25% bupivacaine administered in a supraclavicular single shot perineural injection

Locations (1)

UNC Chapel Hill

Chapel Hill, North Carolina, United States