Clinical Research Directory

Inclusion Criteria: * Female and male healthy individuals (ASA I: assessed according to the American Society of Anesthesiologists Physical Status Classification System a non-acute or chronic disease), non-pregnant, non-smokers, non-drug-users, and presenting no or minimal alcohol use. * Age: 18 to 35 years * Capacity to give consent * Written consent after detailed information. Exclusion criteria: * Individuals who do not meet all inclusion criteria * Previous brain surgery * History of epileptic seizures * History of psychiatric or neurological disease * Physical status other than American Society of Anesthesiologists physical status I, e.g., presence of severe internal or systemic disease * Chronic intake of medication or drugs (Alcohol, Marihuana, Cocaine, Opioids, Benzodiazepine, etc.) * Impaired hearing or presence of deafness * Absence of fluency in the German language * Known disposition to malignant hyperthermia * Previous diagnosis of hepatic porphyria * Body mass index greater than 30 kg/m2 * Gastrointestinal disorders with a disposition for gastroesophageal regurgitation * Known or suspected difficult airway * Known hypersensitivity to propofol or any propofol injectable emulsion components (i.e., eggs, eggs products, soybeans, or soy products) * Atopy/severe allergies/asthma * Cardiological abnormalities: torsades de pointes, prolonged QT interval, QT changes present since birth. * Contraindications to MRI (e.g., pacemakers, artificial heart valves, cardioseal, aneurysm clips, implanted magnetic metal parts (screws, plates from surgery), cochlear implants, metal splitters/grenade splinters, acupuncture needle, insulin pump, piercings that cannot be removed, etc) * Pregnancy * Subjects with claustrophobia