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Hitting the Mark: Introducing State-of-the-art MRI for Precision Radiotherapy of Glioblastoma
Sponsor: Erasmus Medical Center
Summary
The goal of this prospective cohort study is to assess the potential of advanced MRI for improved radiotherapy target delineation in patients diagnosed with glioblastoma. The main questions it aims to answer are: * How does the coverage of the recurrence volume by a radiotherapy plan based on advanced MRI compare to the coverage by the clinical radiotherapy plan? * How does the distribution of the dose to organs at risk by a radiotherapy plan based on advanced MRI compare to the distribution by the clinical radiotherapy plan? Participants will undergo an extended MRI-protocol prior to radiotherapy. This extended MRI-protocol includes the clinical brain tumor imaging protocol plus additional advanced MRI-sequences. Radiation treatment and patient follow-up will occur according to the clinical standard.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
53
Start Date
2024-01-03
Completion Date
2026-08
Last Updated
2025-06-12
Healthy Volunteers
No
Conditions
Interventions
Extended or additional MRI-scan (with contrast) prior to radiotherapy
The MRI-protocol before radiotherapy is extended with 20 minutes. Patients who would not have received an MRI-scan prior to radiotherapy, will get an extra MRI-scan when participating.
Locations (1)
Erasmus Medical Center
Rotterdam, South Holland, Netherlands