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ACTIVE NOT RECRUITING
NCT06187662
NA

BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches

Sponsor: Children's Hospital of Philadelphia

View on ClinicalTrials.gov

Summary

This study will compare two strategies that target distinct determinants of blood culture overuse in an exploratory, hybrid, pilot trial in 8 PICUs. It aims to determine if there is any association between specific strategies used to reduce blood culture overuse on unit-wide blood culture rates, patient safety, and concurrently explore aspects of the implementation process (acceptability, feasibility, appropriateness).

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

8

Start Date

2023-01-01

Completion Date

2027-04

Last Updated

2025-10-31

Healthy Volunteers

Yes

Interventions

BEHAVIORAL

Checklist

This intervention consists of a checklist to guide blood culture decisions, that a clinician in a site randomized to Arm A will be asked to consult and complete prior to ordering or not ordering a blood culture; as the relevant clinical scenario occurs. Meaning, if a clinician in Arm A is faced with a scenario in which it is customary or usual care to consider a blood culture, the clinician will be asked to first review this checklist. The checklist is not a binding or absolute process - the clinician should use both the checklist and typical clinical judgment to decide if the blood culture test is needed or not. The checklist is based on prototypes used in the completed parent study, BrighT STAR and the earlier preliminary studies at Johns Hopkins.

BEHAVIORAL

Targeted Messaging

This intervention consists of targeted messaging and education that the primary study team will create and ask the Arm B sites to deliver to the PICU clinicians, which focuses on the importance of diagnostic stewardship and the current evidence for the benefit/low risk nature of the stewardship program to date.

Locations (8)

UCLA Mattel Children's Hospital

Los Angeles, California, United States

UCSF Benioff Children's Hospital Mission Bay

San Francisco, California, United States

Nemours / AI DuPont Hospital for Children

Wilmington, Delaware, United States

Riley Hospital for Children

Indianapolis, Indiana, United States

Norton Children's Hospital

Louisville, Kentucky, United States

Kravis Children's Hospital

New York, New York, United States

New York-Presbyterian Morgan Stanley Children's Hospital

New York, New York, United States

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, United States