Clinical Research Directory

Inclusion Criteria: 1. Documented non-valvular atrial fibrillation and contraindicated for long-term oral anticoagulation, or in those who are taking oral warfarin but still develop stroke or relevant events 2. Meets the current device indications and per physician discretion for Amulet implant 3. Able to provide written Informed Consent prior to any study related procedures 4. 18 years of age or older at the time of enrolment Exclusion Criteria: 1. With the presence of intracardiac thrombus 2. With active endocarditis or other infections producing bacteremia 3. Patients whose low risk of stroke (CHA2DS2-VASC score is 0 or 1) or bleeding (HAS-BLED score \< 3) 4. Where placement of the device would interfere with any intracardiac or intravascular structures 5. Has a life expectancy of less than 2 years due to any condition 6. Currently participating or planning on participating during the follow up period of this study in a clinical study that includes an active treatment arm or a concurrent clinical study which may confound the results of this trial