Clinical Research Directory

Inclusion Criteria for Cases: * age 18-75 years * moderate-severe OSA (defined as AHI ≥15 events/hour) * willing to accept PAP therapy Inclusion Criteria for Controls: * age 18-75 years * no OSA (defined as AHI \<5 events/hour) Exclusion Criteria for Cases: * current use of PAP or other OSA treatments * home oxygen therapy * recent changes (within 3 months) to BP medications among those who are on these medications * presence of Cheyne-Stokes Respiration (CSR) in sleep study * predominantly central sleep apnea (AHI≥15 events/hour, with \>50% central events) * pregnancy * clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant * organ transplantation * self-reported sleep duration less than 5 hours per night on weeknights (work nights) * current night shift work Exclusion Criteria for Controls: * home oxygen therapy * pregnancy * clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant * organ transplantation * self-reported sleep duration less than 5 hours per night on weeknights (work nights) * current night shift work