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Impact of Gravity on Cardiac Hemodynamics
Sponsor: University Hospital, Caen
Summary
The goal of this clinical trial is to define and compare pre-load dependance of the cardiac function according to the intracardiac hydrostatic gradient of pressure in healthy and diabetic populations. Participants will undergo 4 tilt angle and 4 lower body negative pressure intensities during which cardiovascular data will be assessed and a transthoracic echography will be performed.
Official title: Effect of Intra-cardiac Hydrostatic Pressure Gradient in Cardiac Filling and Ejection
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2023-11-22
Completion Date
2025-10-15
Last Updated
2025-03-26
Healthy Volunteers
Yes
Conditions
Interventions
Cardiovascular and Baroreflex stimulation by Tilting
Tilt of the patient at 4 angles (22°, 42°, 58° and 80°), the order is randomized for 3 angles (22°, 42°, 58°) while 80° will always be last.
Cardiovascular and Baroreflex stimulation by Lower Body Negative Pressure
The patient will undergo 4 level of LBNP (10Torr, 20Torr, 35Torr, 50Torr), the order is randomized for 3 intensities (10Torr, 20Torr, 35Torr) while 50Torr will always be last.
Locations (1)
Inserm 1075 Comete, Unicaen
Caen, France