Clinical Research Directory

Inclusion Criteria: 1. Age greater than 65 years old, regardless of gender 2. ASA is classified as Class II and III; 3. BMI 18-28 kg/m2; 4. Patients undergoing examination or treatment outside the operating room; 5. FRAIL scale score ≥ 3 points 6 The patient voluntarily participated in this study and signed an informed consent form. Exclusion Criteria: 1 Those who are allergic or contraindicated to drugs such as benzodiazepines, opioids, propofol, and their drug components; 2\. Acute heart failure; Unstable angina pectoris; Myocardial infarction occurred within 6 months prior to screening; Resting electrocardiogram heart rate\<50 beats/minute; Third degree atrioventricular transmission delay; Severe arrhythmia; Moderate to severe heart valve disease; 3\. Patients with severe respiratory diseases (acute respiratory infections, acute exacerbations of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 4\. Patients who have not received formal antihypertensive treatment or have poor blood pressure control; 5\. Patients with traumatic brain injury, possible presence of intracranial hypertension, cerebral aneurysms, history of cerebrovascular accidents, and central nervous system diseases; 6\. Individuals with mental system diseases (schizophrenia, mania, bipolar disorder, mental disorder, etc.), long-term history of taking psychotropic drugs, and cognitive impairment; 7\. Other situations that have been determined by the researcher to be unsuitable for inclusion.