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Overfeeding Induced Fat-tissue Stimulation
Sponsor: German Diabetes Center
Summary
Type 2 diabetes is the most common metabolic disease worldwide, characterized by hyperglycemia, decreased whole body insulin sensitivity, and white adipose tissue (WAT) dysfunction. A key factor in its development is chronic overnutrition, usually with a high-fat diet (HFD), leading to disturbances of glucose and lipid metabolism. However, the mechanism of short-term HFD-induced tissue-specific insulin resistance remains poorly understood. This project aims to further unravel the underlying mechanisms of short-term HFD overnutrition-mediated WAT insulin resistance. The model described here corresponds to a randomized, single- blinded parallel-grouped trial, consisting of two interventions: a macronutrient-balanced diet and or a hypercaloric diet over three weeks in order to investigate differences in interorgan fatty acid and glucose metabolism between the studied groups. Based on recent studies, the hypothesis is that 21-day hypercaloric HFD induces WAT insulin resistance via a diacylglycerol, novel protein kinase C-insulin receptor signaling model in both fasting and insulin-stimulated states.
Official title: Short-term High-fat Overnutrition Induces Insulin Resistance in White Adipose Tissue
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2024-01-31
Completion Date
2030-12-31
Last Updated
2024-03-01
Healthy Volunteers
Yes
Conditions
Interventions
High-fat overnutrition
Overnutrition: 40% higher lipid consumption per day than required
Normocaloric macronutrient-balanced nutrition
Normocaloric, macronutrient-balanced nutrition: Calories requirement for weight maintenance \[(kcal/d) 55% carbohydrates, 15% proteins, 30% fat\]
Locations (1)
Georgia Xourafa
Düsseldorf, North Rhine-Westphalia, Germany