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Improving Status Epilepticus Treatment Times
Sponsor: Nationwide Children's Hospital
Summary
This is a stepped-wedge cluster randomized effectiveness-implementation hybrid study aimed at determining the effect of dissemination of a QI bundle on the time to treatment of SE among hospitalized, non-critically ill children. The primary study endpoint is to decrease the time from the SE diagnosis to treatment with the first dose of a benzodiazepine (BZD) as measured during hospitalization, which will decrease chances of morbidity and mortality.
Official title: Quality Improvement in Time to Treatment of Status Epilepticus
Key Details
Gender
All
Age Range
30 Days - 18 Years
Study Type
INTERVENTIONAL
Enrollment
450
Start Date
2024-02-01
Completion Date
2027-03-31
Last Updated
2026-04-01
Healthy Volunteers
No
Conditions
Interventions
Quality improvement bundle
(1) standardizing BZD default to intranasal or buccal midazolam; (2) targeting initial BZD treatment within 10 minutes of seizure onset; (3) relocating and bundling all administration items needed to the hospital unit medication room; (4) utilizing basic seizure first aid in the initial patient assessment; (5) developing and implementing SE-specific EHR documentation; (6) multidisciplinary QI teams
Quality improvement bundle and local PDSA cycles with central support
Sites will implement both the standard QI bundle as well as site-specific PDSA cycles with central data and methods support.
Quality improvement bundle and local PDSA cycles without central support
Sites will implement both the standard QI bundle as well as site-specific PDSA cycles without central data or methods support.
Locations (1)
Nationwide Children's Hospital
Columbus, Ohio, United States