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RECRUITING
NCT06195605
NA

Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin

Sponsor: University of Michigan

View on ClinicalTrials.gov

Summary

The purpose of the study is to investigate the impact of the injection of dermal filler on the quality of the skin dermal extracellular matrix in persons between the ages of 30-50 years. The quality of the dermal extracellular matrix will be assessed following injection of dermal filler compared to injection of saline vehicle.

Key Details

Gender

All

Age Range

30 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

15

Start Date

2024-05-09

Completion Date

2026-11

Last Updated

2025-07-08

Healthy Volunteers

No

Conditions

Interventions

DEVICE

Restylane-L

Using a small gauge metal hub needle, two injections of CL-HA dermal filler (Restylane-L) will be performed, each into a small area (approximately 2 x 2 cm) of the mid-dermis of a forearm of a subject. Each injection will be 0.5 cc in volume, and will be approximately 2 cm apart from each other

DEVICE

Vehicle

Two injections of vehicle will be performed in the same manner as Restylane-L and in the same forearm, totaling 4 injections. A plastic template will be used to track the location of the injections, relative to landmarks on the skin.

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States