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Tumor Microenvironment in Gastric Cancer Patients Treated With Combined Immunotherapy and Chemotherapy
Sponsor: Chinese PLA General Hospital
Summary
The goal of this study is to analyze the tumor microenvironment (TME) in gastric cancer patients treated with combined immunotherapy and chemotherapy. The main questions it aims to answer are: * Provide profiles of TME between pre-treatment and post-treatment to gain insights into the mechanisms of immunotherapy combined with chemotherapy in advanced gastric cancer * Investigate the crucial factors affecting treatment efficacy by comparing gastric cancer patients with varying treatment responses
Official title: Using Single-cell Sequencing to Explore Tumor Microenvironment in Gastric Cancer Patients Treated With Combined Immunotherapy and Chemotherapy
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
15
Start Date
2022-07-01
Completion Date
2026-10-09
Last Updated
2026-10-15
Healthy Volunteers
No
Interventions
SOX plus PD-1 inhibitor
S-1, Oxaliplatin and nivolumab/sintilimab
Gastroscopic biopsy
Gastroscopy and biopsy
Locations (1)
Chinese PLA General Hospital
Beijing, Beijing Municipality, China