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Atrophic Gastritis Predicts the Risk of Gastric Cancer
Sponsor: Shanghai Jiao Tong University School of Medicine
Summary
Despite declining incidence rates, gastric cancer (GC) ranks the fourth leading cause of cancer-related mortality and the fifth most common cancer worldwide, with the highest incidence reported in Eastern Asia. The 5-year overall survival rate of early GC exceeds 90%, which was well above advanced GC. Most intestinal-type GCs follow the Correa cascade-inflammation,atrophy, intestinal metaplasia (IM), dysplasia and subsequent carcinoma. The presence of gastric mucosal atrophy and intestinal metaplasia are important risk factors for GC. The purpose of this study was to investigate the incidence of GC attributed to atrophic gastritis in a region with high incidence of GC.
Official title: Atrophic Gastritis Predicts the Risk of Gastric Cancer: a Prospective Cohort Study
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
2042
Start Date
2023-12-15
Completion Date
2034-12-31
Last Updated
2024-12-30
Healthy Volunteers
No
Conditions
Interventions
Esophagogastroscopy (OLGA 0-Ⅰ)
Surveillance endoscopies at years 3-5.
Esophagogastroscopy (OLGA II)
Surveillance endoscopies at years 2-3.
Esophagogastroscopy (OLGA III-IV)
Surveillance endoscopies every year.
Locations (1)
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China