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Stepcare Extended Follow-up Substudy
Sponsor: Region Skane
Summary
To provide detailed information on long-term outcomes in relation to potential neuroprotection and improvements in recovery for different targets of sedation, temperature, and pressure management in post out of hospital cardiac arrest survivors at 6 and 12 months. In addition, the impact of caring for a post OHCA survivor will be explored.
Official title: Extended Follow-up Substudy of the Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation -STEPCARE Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
600
Start Date
2023-08-01
Completion Date
2027-07-31
Last Updated
2025-04-23
Healthy Volunteers
No
Conditions
Interventions
Feed back controlled temperature device
If core temperature exceeds 37.7 degrees celsius a feedback controlled-device will be used at set to 37.5 degrees celsius
High MAP
A mean arterial blood pressure (MAP) of \>85mmHg will be used. Vasopressors will be titrated to this target during 36 hours
Deep sedation
Deep sedation for at least 36 hours
Fever control without a device
Management of fever in the intensive care unit without a device
Low MAP
A mean arterial blood pressure (MAP) of \>65mmHG will be used. Vasopressors will be titrated to this target during 36 hours
Minimal sedation
A strategy of minimal sedation in the intensive care unit, used only as needed to facilitate transport, imaging and invasive procedures
Locations (34)
Princess Alexandra Hospital
Brisbane, Australia
The Sutherland Hospital
Caringbah, Australia
The Prince Charles Hospital
Chermside, Australia
Nepean hospital
Kingswood, Australia
St George hospital
Kogarah, Australia
Liverpool hospital
Liverpool, Australia
Austin hospital
Melbourne, Australia
Royal North Shore Hospital
Sydney, Australia
Ziekenhuis Oost Limburg
Genk, Belgium
Ghent university hospital
Ghent, Belgium
Helsinki Helsingfors university central hospital
Helsinki, Finland
Jorvi hospital
Jorvi, Finland
Tampere university hospital
Tampere, Finland
Charite university hospital
Berlin, Germany
Universitäres Herzzentrum Lübeck Universitätsklinikum Schleswig-Holstein
Lübeck, Germany
Tubingen university hospital
Tübingen, Germany
Centre Hospitalier de Luxembourg
Luxembourg, Luxembourg
Auckland city hospital
Auckland, New Zealand
Middlemore hospital
Auckland, New Zealand
Christchurch hospital
Christchurch, New Zealand
Wellington hospital
Wellington, New Zealand
Sorlandet hospital
Arendal, Norway
Oslo university hospital Rikshospitalet
Oslo, Norway
Sahlgrenska university hospital
Gothenburg, Sweden
Hallands hospital
Hålland, Sweden
Helsingborg hospital
Helsingborg, Sweden
Skåne university hospital
Lund, Sweden
Skåne university hopsital
Malmo, Sweden
Bern university hospital
Bern, Switzerland
Kantonsspital St. Gallen
Sankt Gallen, Switzerland
The Essex Cardiothoracic Centre
Basildon, United Kingdom
Bristol Royal Infirmary
Bristol, United Kingdom
University hospital of Wales
Cardiff, United Kingdom
St Bartholomew's hospital
London, United Kingdom