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ACTIVE NOT RECRUITING
NCT06211036
PHASE3

Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab

Sponsor: Amgen

View on ClinicalTrials.gov

Summary

The primary objective of this study is to compare the efficacy of tarlatamab plus durvalumab with durvalumab alone on prolonging overall survival (OS).

Official title: A Phase 3, Open-label, Multicenter, Randomized Study of Tarlatamab in Combination With Durvalumab vs Durvalumab Alone in Subjects With Extensive-Stage Small-Cell Lung Cancer Following Platinum, Etoposide and Durvalumab (DeLLphi-305)

Key Details

Gender

All

Age Range

18 Years - 99 Years

Study Type

INTERVENTIONAL

Enrollment

563

Start Date

2024-06-05

Completion Date

2028-09-30

Last Updated

2025-12-17

Healthy Volunteers

No

Interventions

DRUG

Tarlatamab

Intravenous (IV) infusion

DRUG

Durvalumab

IV infusion

Locations (219)

Infirmary Cancer Center

Mobile, Alabama, United States

University of Southern California

Los Angeles, California, United States

Yale New Haven Hospital

New Haven, Connecticut, United States

University Cancer and Blood Center LLC

Athens, Georgia, United States

Emory University

Atlanta, Georgia, United States

Northeast Georgia Medical Center

Gainesville, Georgia, United States

University of Illinois Chicago

Chicago, Illinois, United States

Franciscan Health Indianapolis

Indianapolis, Indiana, United States

Our Lady of the Lake Cancer Institute

Baton Rouge, Louisiana, United States

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

Cancer and Hematology Centers of Western Michigan

Grand Rapids, Michigan, United States

Mayo Clinic

Rochester, Minnesota, United States

Allina Health System dba Allina Health Cancer Institute

Saint Paul, Minnesota, United States

Oncology Hematology Associates

Springfield, Missouri, United States

Nebraska Cancer Specialists

Omaha, Nebraska, United States

Astera Cancer Care

East Brunswick, New Jersey, United States

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, United States

Montefiore Medical Center - Bronx

The Bronx, New York, United States

Duke University

Durham, North Carolina, United States

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

Oncology Hematology Care Incorporated

Cincinnati, Ohio, United States

University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States

The Ohio State University

Columbus, Ohio, United States

Oncology Associates of Oregon, PC

Eugene, Oregon, United States

Oregon Health and Science University

Portland, Oregon, United States

Allegheny Health Network

Pittsburgh, Pennsylvania, United States

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

Medical University of South Carolina

Charleston, South Carolina, United States

Baptist Cancer Center Memphis Thoracic

Memphis, Tennessee, United States

Sarah Cannon Research Institute

Nashville, Tennessee, United States

Texas Oncology - Dallas Fort Worth

Dallas, Texas, United States

US Oncology Research Investigational Products Center

Dallas, Texas, United States

University of Texas MD Anderson Cancer Center

Houston, Texas, United States

Virginia Oncology Associates

Newport News, Virginia, United States

Virginia Commonwealth University Massey Cancer Center

Richmond, Virginia, United States

Swedish Cancer Institute

Seattle, Washington, United States

The Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Hospital Britanico de Buenos Aires

CABA, Buenos Aires, Argentina

Instituto Alexander Fleming

Capital Federal, Buenos Aires, Argentina

Fundacion Medica de Rio Negro y Neuquen

Cipolletti, Río Negro Province, Argentina

Exelsus Oncologia Clinica

San Miguel de Tucumán, Tucumán Province, Argentina

Fundacion Centro Oncológico Riojano Integral para la Investigación y Prevención del Cáncer

La Rioja, Argentina

Chris OBrien Lifehouse

Camperdown, New South Wales, Australia

Wollongong Hospital

Wollongong, New South Wales, Australia

Greenslopes Private Hospital

Greenslopes, Queensland, Australia

Cancer Research South Australia

Adelaide, South Australia, Australia

Monash Medical Centre

Clayton, Victoria, Australia

Sir Charles Gairdner Hospital

Nedlands, Western Australia, Australia

Medizinische Universitaet Graz

Graz, Austria

Universitaetsklinikum Krems

Krems, Austria

Landeskrankenhaus Feldkirch

Rankweil, Austria

Azorg Campus Aalst - Moorselbaan

Aalst, Belgium

Universitair Ziekenhuis Brussel

Brussels, Belgium

Universite Catholique de Louvain Cliniques Universitaires Saint Luc

Brussels, Belgium

Institut Jules Bordet

Brussels, Belgium

Universitair Ziekenhuis Antwerpen

Edegem, Belgium

Ziekenhuis Oost-Limburg

Genk, Belgium

Algemeen Ziekenhuis Maria Middelares

Ghent, Belgium

Centres Hospitaliers Universitaires - Helora - Hopital de Mons - Site Kennedy

Mons, Belgium

Centre Hospitalier Universitaire-Universite Catholique de Louvain Namur-Site Godinne

Yvoir, Belgium

Hospital Sao Rafael-Idor

Salvador, Estado de Bahia, Brazil

Cenantron Centro Avançado de Tratamento Oncologico Ltda

Belo Horizonte, Minas Gerais, Brazil

Santa Casa de Misericordia de Passos

Passos, Minas Gerais, Brazil

Hospital Uopeccan

Cascavel, Paraná, Brazil

Hospital de Clinicas de Ijui

Ijuí, Rio Grande do Sul, Brazil

Hospital de Clinicas de Passo Fundo

Passo Fundo, Rio Grande do Sul, Brazil

Irmandade da Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Fundacao Antonio Prudente AC Camargo Cancer Center

São Paulo, São Paulo, Brazil

Hospital Israelita Albert Einstein

São Paulo, São Paulo, Brazil

Oncoclinicas Rio de Janeiro S A

Rio de Janeiro, Brazil

London Health Sciences Centre

London, Ontario, Canada

CHU de Quebec Hopital de l Enfant Jesus

Québec, Quebec, Canada

Beijing Chaoyang Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Beijing Cancer Hospital

Beijing, Beijing Municipality, China

Xinqiao Hospital

Chongqing, Chongqing Municipality, China

Fujian Cancer Hospital

Fuzhou, Fujian, China

The Second Attached Hospital Of Fujian Medical University

Quanzhou, Fujian, China

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

Affiliated Hospital of Guilin Medical University

Guilin, Guangxi, China

Guangxi Medical University Affiliated Tumor Hospital

Nanning, Guangxi, China

Cangzhou Peoples Hospital

Cangzhou, Hebei, China

Jiamusi Cancer Hospital

Jiamusi, Heilongjiang, China

Henan Cancer Hospital

Zhengzhou, Henan, China

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

Hubei Cancer Hospital

Wuhan, Hubei, China

The Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, China

Nanjing Chest Hospital

Nanjing, Jiangsu, China

Xuzhou Central Hospital

Xuzhou, Jiangsu, China

Jiangxi Cancer hospital

Nanchang, Jiangxi, China

Jilin Cancer Hospital

Changchun, Jilin, China

The Affiliated Cancer Hospital of Shandong First Medical University

Jinan, Shandong, China

Linyi Cancer Hospital

Linyi, Shandong, China

Shanghai Chest Hospital

Shanghai, Shanghai Municipality, China

Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

Shanxi Provincial Cancer Hospital

Taiyuan, Shanxi, China

The First Affiliated Hospital of Xian Jiaotong University

Xi’an, Shanxi, China

West China Hospital of Sichuan University

Chengdu, Sichuan, China

Tianjin Peoples Hospital

Tianjin, Tianjin Municipality, China

Affiliated Cancer Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, China

the First Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

The First Affiliated Hospital Of Ningbo University

Ningbo, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China

Beijing Cancer Hospital

Beijing, China

Fakultni nemocnice Brno

Brno, Czechia

Fakultni nemocnice Olomouc

Olomouc, Czechia

Nemocnice Agel Ostrava-Vitkovice as

Ostrava-Vitkovice, Czechia

Vseobecna fakultni nemocnice v Praze

Prague, Czechia

Fakultni nemocnice v Motole

Prague, Czechia

Rigshospitalet

Copenhagen, Denmark

Regionshospitalet Godstrup

Herning, Denmark

Odense Universitetshospital

Odense C, Denmark

Institut Bergonie

Bordeaux, France

Centre Hospitalier Regional Universitaire de Brest - Hopital Morvan

Brest, France

Centre Hospitalier Intercommunal de Creteil

Créteil, France

Centre Hospitalier - Le Mans

Le Mans, France

Centre Leon Berard

Lyon, France

Centre Hospitalier Universitaire Nord

Marseille, France

Institut regional du Cancer Montpellier

Montpellier, France

Hopital Cochin

Paris, France

Centre Hospitalier Universitaire de Nantes - Hopital Nord Laennec

Saint-Herblain, France

Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil

Strasbourg, France

Centre Hospitalier Universitaire de Toulouse - Hopital Larrey

Toulouse, France

Clinique Teissier

Valenciennes, France

Kliniken der Stadt Koeln gGmbH

Cologne, Germany

Universitaetsklinikum Dresden

Dresden, Germany

Universitaetsklinikum Essen

Essen, Germany

Asklepios Fachkliniken Muenchen Gauting

Gauting, Germany

LungenClinic Grosshansdorf GmbH

Großhansdorf, Germany

Universitaetsklinikum Heidelberg

Heidelberg, Germany

University Hospital Muenster

Münster, Germany

Universitaetsklinikum Wuerzburg

Würzburg, Germany

Henry Dunant Hospital Center

Athens, Greece

Sotiria General Hospital

Athens, Greece

Attikon University Hospital

Athens, Greece

Metropolitan General

Athens, Greece

Metropolitan Hospital

Athens, Greece

Saint Lukes Hospital SA

Thessaloniki, Greece

European Interbalkan Medical Center

Thessaloniki, Greece

Princess Margaret Hospital

Kowloon, Hong Kong

Prince of Wales Hospital, Chinese University of Hong Kong

Shatin, New Territories, Hong Kong

Semmelweis Egyetem

Budapest, Hungary

Orszagos Koranyi Pulmonologiai Intezet

Budapest, Hungary

Matrai Gyogyintezet

Gyöngyös, Hungary

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz

Győr, Hungary

Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz

Székesfehérvár, Hungary

Reformatus Pulmonologiai Centrum

Törökbálint, Hungary

Beaumont Hospital

Dublin, Ireland

Rambam Medical Center

Haifa, Israel

Shaare Zedek Medical Center

Jerusalem, Israel

Meir Medical Center

Kfar Saba, Israel

Rabin Medical Center

Petah Tikva, Israel

IRCCS Istituto Tumori Giovanni Paolo II

Bari, Italy

IRCCS Istituto Oncologico Europeo

Milan, Italy

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Milan, Italy

Centro Ricerche Cliniche Di Verona Societa responsabilita limitata

Verona, Italy

Aichi Cancer Center

Nagoya, Aichi-ken, Japan

National Cancer Center Hospital East

Kashiwa-shi, Chiba, Japan

National Hospital Organization Shikoku Cancer Center

Matsuyama, Ehime, Japan

Kyushu University Hospital

Fukuoka, Fukuoka, Japan

Kurume University Hospital

Kurume-shi, Fukuoka, Japan

National Hospital Organization Hokkaido Cancer Center

Sapporo, Hokkaido, Japan

Hyogo Cancer Center

Akashi-shi, Hyōgo, Japan

Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center

Yokohama, Kanagawa, Japan

Niigata Cancer Center Hospital

Niigata, Niigata, Japan

Okayama University Hospital

Okayama, Okayama-ken, Japan

Kansai Medical University Hospital

Hirakata-shi, Osaka, Japan

Osaka International Cancer Institute

Osaka, Osaka, Japan

Kindai University Hospital

Osakasayama-shi, Osaka, Japan

Saitama Medical University International Medical Center

Hidaka-shi, Saitama, Japan

Shizuoka Cancer Center

Sunto-gun, Shizuoka, Japan

Juntendo University Hospital

Bunkyo-ku, Tokyo, Japan

National Cancer Center Hospital

Chuo-ku, Tokyo, Japan

The Cancer Institute Hospital of Japanese Foundation for Cancer Research

Koto-ku, Tokyo, Japan

Wakayama Medical University Hospital

Wakayama, Wakayama, Japan

Health Pharma Professional Research SA de CV

Mexico City, Mexico City, Mexico

Oncare

Mexico City, Mexico City, Mexico

Universitair Medisch Centrum Groningen

Groningen, Netherlands

Maastricht Universitair Medisch Centrum

Maastricht, Netherlands

Erasmus Medisch Centrum

Rotterdam, Netherlands

Uniwersyteckie Centrum Kliniczne

Gdansk, Poland

Wielkopolskie Centrum Pulmonologii i Torakochirurgii imienia Eugenii i Janusza Zeylandow

Poznan, Poland

Instytut Gruzlicy i Chorob Pluc

Warsaw, Poland

Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii

Wroclaw, Poland

Hospital da Luz, SA

Lisbon, Portugal

Hospital Cuf Descobertas

Lisbon, Portugal

Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano

Matosinhos Municipality, Portugal

Hospital Cuf porto

Porto, Portugal

Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca

Cluj-Napoca, Romania

Spitalul Municipal Ploiesti

Ploieşti, Romania

Chungbuk National University Hospital

Cheongju Chungbuk, South Korea

National Cancer Center

Goyang-si Gyeonggi-do, South Korea

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Seoul National University Hospital

Seoul, South Korea

Severance Hospital Yonsei University Health System

Seoul, South Korea

Asan Medical Center

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Hospital Regional Universitario de Malaga

Málaga, Andalusia, Spain

Hospital Universitario Virgen Macarena

Seville, Andalusia, Spain

Hospital Universitari Vall d Hebron

Barcelona, Catalonia, Spain

Hospital Clinic i Provincial de Barcelona

Barcelona, Catalonia, Spain

Hospital de la Santa Creu i Sant Pau

Barcelona, Catalonia, Spain

Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals

L'Hospitalet de Llobregat, Catalonia, Spain

Clinica Universidad de Navarra

Pamplona, Navarre, Spain

Hospital Universitari i Politecnic La Fe

Valencia, Valencia, Spain

Hospital Universitario Ramon y Cajal

Madrid, Spain

Universitaetsspital Basel

Basel, Switzerland

Inselspital Bern

Bern, Switzerland

Ospedale Regionale di Bellinzona e Vali

Mendrisio, Switzerland

Kantonsspital Sankt Gallen

Sankt Gallen, Switzerland

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

Ankara Bilkent Sehir Hastanesi

Ankara, Turkey (Türkiye)

Bagcilar Medipol Mega Universite Hastanesi

Istanbul, Turkey (Türkiye)

Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma Hastanesi

Izmir, Turkey (Türkiye)

Medical Park Seyhan Hastanesi

Mersin, Turkey (Türkiye)

VM Medical Park Mersin Hastanesi

Mersin, Turkey (Türkiye)

Sakarya Egitim ve Arastirma Hastanesi

Sakarya, Turkey (Türkiye)