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Transcranial Alternating Current Stimulation in Patients With Disorders of Consciousness
Sponsor: First Affiliated Hospital of Zhejiang University
Summary
In recent years, many literatures have reported that tACS, as a non-invasive electrical brain stimulation technique, has been applied in depression, schizophrenia, dementia and other fields. The goal of this study is to explore the clinical efficacy and mechanism of action of HD-tACS in patients with chronic disorders of consciousness.The main questions it aims to answer are: 1. Explore the neurophysiological effects of HD-tACS on patients with chronic disorders of consciousness under theta and gamma frequency stimulation, and observe its impact on behavioral changes and long-term prognosis; 2. Further investigate the awakening mechanism of consciousness disorders through HD-tACS stimulation using multimodal assessment; 3. Clarify the role of theta and gamma neural oscillations in consciousness disorders, providing new targets for the pathogenesis and treatment of Disorders of Consciousness .
Official title: Clinical Study on Efficacy and Mechanism of HD-tACS in Patients With Prolonged Disorders of Consciousness
Key Details
Gender
All
Age Range
14 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
64
Start Date
2024-01-12
Completion Date
2025-01-20
Last Updated
2026-07-30
Healthy Volunteers
No
Conditions
Interventions
real transcranial alternating current stimulation
The alternating current was non-invasively delivered using an M×N five-channel high-definition transcranial electrical current stimulator (Soterix Medical). A BrainCap (Brain Vision) embedded with high-definition plastic holders consisted of five 12-mm-diameter Ag/AgCl ring electrodes, filled with conductive gel. During real HD-tACS, the current was increased to 2 mA from the onset of stimulation and applied for 20 minutes.
sham transcranial alternating current stimulation
For the sham condition(sham HD-tACS), the same electrode placement was used as in the stimulation condition, but the current was only applied during the first and last 30 seconds of the entire 20-minute stimulation period.
Locations (1)
The First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China