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ACTIVE NOT RECRUITING

NCT06212128

RAPIDO vs LCRT vs Upfront Surgery - a Prospective Cohort Study

Sponsor: Sengkang General Hospital

View on ClinicalTrials.gov

Summary

Aim: We evaluated the surgical outcomes of 3 groups of patients with rectal cancers - RAPIDO vs standard long course radiotherapy (LCRT) vs upfront surgery to objectively determine the effects of TNT on TME. Methods: A review of prospectively collected data was performed for patients who have rectal cancer and underwent low anterior resection from January 2016 to May 2022. Data on patient demographics, disease staging, peri-operative details and up to 2-year follow-up outcomes were analysed. The surgical and oncological outcomes were compared. Patients were followed up until 31 May 2022.

Official title: Novel Objective Comparison of Short-term Surgical Outcomes From Total Mesorectal Excision Between Total Neoadjuvant Therapy - Rapido Protocol, Standard Long Course Radiotherapy and Upfront Surgery

Key Details

Gender

All

Age Range

21 Years - 99 Years

Study Type

OBSERVATIONAL

Enrollment

Start Date

2016-01-01

Completion Date

2024-12-30

Last Updated

2024-10-23

Healthy Volunteers

Conditions

Rectal Cancer

Interventions

COMBINATION_PRODUCT

RAPIDO TNT

neoadjuvant therapy per RAPIDO protocol (Patients under RAPIDO group underwent 25Gy/5 sessions of short course radiotherapy followed by 6 cycles of neoadjuvant XELOX similar to that of the RAPIDO trial protocol)