Clinical Research Directory

Inclusion Criteria: * ≥18 years of age * Living in the study catchment area * Eligible for TPT according to South African National guidelines(5), i.e. are a) living with HIV or b) are a close contact of a person with TB disease (defined by a person that resides in the same house as a person with TB), c) and in either case * Have screened negative for TB disease in the last 6 months, through TB TRIAGE+ Trial, other household contact tracing, or other community TB screening * Negative TB screening at enrolment (if TB TRIAGE+ screening was more than 3 months ago) * Willing and able to provide written or verbal consent * Participants whom have not received TPT in the last 12 months; this was confirmed verbally with participants during the enrolment process. Exclusion Criteria: * Less than 18 years of age. * Pregnant or planning on pregnancy within next three months * Planning on moving or relocating from the area within the next three months * Positive for active TB * Currently on TB treatment