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A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
Sponsor: Pfizer
Summary
The main purpose of the study is to understand how safe and tolerable is elranatamab when given along with iberdomide. There are 2 parts to this study. Part 1 will look at how safe and tolerable is elranatamab when given with iberdomide. Part 2 will look at the correct amount of this combination that can be given to patients with relapsed or refractory multiple myeloma. Myeloma is a type of cancer that begins in plasma cells (white blood cells that produce antibodies). Refractory means a disease or condition that does not respond to treatment. Relapsed means the return of a disease after a period of improvement. All study medicines are given in cycles that last 28 days. Everyone taking part in this study will receive elranatamab as a shot under the skin. Iberdomide will be taken by mouth once a day for 21 days over a 28-day cycle. Participants will receive study medicine until: * their disease progresses or, * they experience unacceptable side effects or, * they choose to no longer take part in the study. The study will look at the experiences of people receiving the study medicines. This will help see if the study medicines are safe and can be used for multiple myeloma treatment.
Official title: A PHASE 1B, OPEN-LABEL STUDY OF ELRANATAMAB IN COMBINATION WITH IBERDOMIDE IN PARTICIPANTS WITH RELAPSED REFRACTORY MULTIPLE MYELOMA
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
87
Start Date
2024-02-20
Completion Date
2028-03-09
Last Updated
2026-03-27
Healthy Volunteers
No
Conditions
Interventions
Elranatamab
BCMA-CD3 bispecific antibody
Iberdomide
cereblon-modulating agent
Locations (43)
Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center
Coral Gables, Florida, United States
University of Miami Hospital and Clinics Deerfield Beach
Deerfield Beach, Florida, United States
Sylvester Comprehensive Cancer Center- Doral
Doral, Florida, United States
Sylvester Comprehensive Cancer Center
Miami, Florida, United States
University of Miami Hospital and Clinics
Miami, Florida, United States
Sylvester Comprehensive Cancer Center Kendall
Miami, Florida, United States
Sylvester Comprehensive Cancer Center Plantation
Plantation, Florida, United States
Emory University Hospital Midtown
Atlanta, Georgia, United States
Emory University Hospital
Atlanta, Georgia, United States
Winship Cancer Institute
Atlanta, Georgia, United States
Indiana CTSI Clinical Research Center (ICRC)
Indianapolis, Indiana, United States
Indiana University Health University Hospital
Indianapolis, Indiana, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC)
Indianapolis, Indiana, United States
University of Maryland
Baltimore, Maryland, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Dana-Farber Cancer Institute - Chestnut Hill
Newton, Massachusetts, United States
University of Massachusetts Chan Medical School
Worcester, Massachusetts, United States
Methodist Hospital
Omaha, Nebraska, United States
Oncology Hematology West P.C. dba Nebraska Cancer - Methodist
Omaha, Nebraska, United States
Oncology Hematology West P.C. dba Nebraska Cancer Specialists
Omaha, Nebraska, United States
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
MSK Basking Ridge
Basking Ridge, New Jersey, United States
MSK Monmouth
Middletown, New Jersey, United States
MSK Bergen
Montvale, New Jersey, United States
MSK Commack
Commack, New York, United States
MSK Westchester
Harrison, New York, United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy
Long Island City, New York, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
New York, New York, United States
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York, United States
MSK Nassau
Uniondale, New York, United States
Fred Hutchinson Cancer Center
Seattle, Washington, United States
University of Washington
Seattle, Washington, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Liverpool Hospital
Liverpool, New South Wales, Australia
Calvary Mater Newcastle
Waratah, New South Wales, Australia
Townsville University Hospital
Douglas, Queensland, Australia
Epworth Freemasons
East Melbourne, Victoria, Australia
Epworth Hospital
Richmond, Victoria, Australia
Slade Pharmacy
Richmond, Victoria, Australia
Dr. Everett Chalmers Regional Hospital
Fredericton, New Brunswick, Canada
CIUSSS de l'Est-de-l'Île-de-Montréal
Montreal, Quebec, Canada
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer
Sherbrooke, Quebec, Canada