Clinical Research Directory

Inclusion Criteria in LEAD group: * Fontaine I-IV class symptoms * Confirmed diagnosis of LEAD Inclusion Criteria in control group: * Age 35-85 * Has to have at least of the following: hypertension, diabetes, coronary artery disease or the patient smokes Exclusion Criteria: * Age \<35 or \>85 years * BMI ≥40 kg/m² * Known heart failure in history * Any acute or chronic autoimmune or rheumatic disease * Cardiac structural disease in history: inflammatory, infiltrative diseases, nonischemic cardiomyopathies * Acute coronary syndrome in last 3 months * Moderate to severe cardiac valvular disease * Cardiac valvular disease operative/invasive treatment in history * Cardiac implantable electronic device (CIED) * Transitory ischemic attack or stroke in last 3 months * Severe COPD (GOLD C or D) * Moderate to severe asthma (according to GINA 2022 criteria) * Untreated hypertension (noninvasive blood pressure measurement ≥180/110 mmHg during recruitment) * Chronic severe kidney dysfunction (eGFR \<30 ml/min/1,73 m²) * Malignant tumor with radiation treatment to thorax, oncologic or biologic treatment in history * Chronic hematologic disease (except for anemia) * Severe liver dysfunction * Malignant tumor with \<5 years of remission * Acute or chronic infectious disease * Anemia with hemoglobin \<80 g/L