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Evaluation of Amino Acid Metabolism Changes in Ovarian Cancer
Sponsor: University Hospital, Grenoble
Summary
Ovarian cancer is associated with undernutrition in more than half of all cases. The current management of undernutrition-cachexia in cancer is not specific. It is well recognized that the nutritional support currently offered to cancer patients is not effective in combating cachexia, which progresses inexorably, leading to the patient's death. It is therefore necessary to offer specific and adapted care, in particular by optimizing the quality of nitrogen intake. To achieve this, the investigators first need to define the specific amino acid requirements of cancer patients.
Official title: Evaluation of Amino Acid Metabolism Changes in Participants With Ovarian Cancer by Dynamic Test
Key Details
Gender
FEMALE
Age Range
40 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
23
Start Date
2024-03-11
Completion Date
2026-12
Last Updated
2024-05-20
Healthy Volunteers
Yes
Conditions
Interventions
dynamic test for amino acid metabolism
Subjects are fasting, and the dynamic test is performed as follows: Placement of 1 peripheral venous line (for infusions). * H0-H1.5: infusion of a 10% glucose solution at increasing flow rate (3 steps of 30 min each: 0.06g/kg/h then 0.12g/kg/h then 0.25g/kg/h of glucose) * H1,5: initial blood sampling (amino acid assay) * H1.5-H4.5: infusion of amino acid solution (Aminoven 5%, Fresenius Kabi, Sèvres, France) at constant speed (flow rate 10.5 mg/kg/h of nitrogen or 1.30 ml/kg/H) in Y with glucose infusion (0.25g/kg/h of glucose) * H4.5: Final blood sampling (amino acid assay) Each amino acid is plotted as a function of its perfusion rate on the abscissa and its variation in plasma concentration on the ordinate.
Locations (1)
CHU Grenoble Alpes
La Tronche, France