Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effect of Pulsatile Hormone Administration on Insulin Action
Sponsor: Pennington Biomedical Research Center
Summary
In humans, insulin is secreted in pulses from the pancreatic beta-cells, and these oscillations help to maintain fasting plasma glucose levels within a narrow normal range. Given the fluctuations in insulin concentrations, oscillations enhance precision of control. The hyperinsulinemic euglycemic clamp test (clamp) involves a continuous infusion of insulin and is the gold standard for measuring insulin sensitivity. In this study, insulin sensitivity measured using the standard clamp will be compared with a clamp in which the same total amount of insulin as the standard clamp is infused every five minutes instead of continuously.
Key Details
Gender
All
Age Range
50 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2024-03-04
Completion Date
2025-12
Last Updated
2025-01-16
Healthy Volunteers
No
Conditions
Interventions
Continuous Insulin administration during hyperinsulinemic euglycemic clamp test
Participants will receive insulin delivered continuously during the hyperinsulinemic euglycemic clamp test
Pulsatile Insulin administration during hyperinsulinemic euglycemic clamp test
Participants will receive insulin delivered every five minutes during the hyperinsulinemic euglycemic clamp test
Locations (1)
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States