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FFR Versus IVUS With Angiography-Derived FFR for Clinical Outcomes in Patients With Coronary Artery Disease
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Summary
To compare the clinical outcomes of fractional flow reserve (FFR)-guided strategy versus intravascular ultrasound (IVUS)-guided stent implantation after angiography-derived FFR-based decision-making.
Official title: Comparison of Fractional Flow Reserve-Guided Strategy Versus Intravascular Ultrasound-Guided Stent Implantation After Angiography-Derived Fractional Flow Reserve-based Decision-Making (The FLAVOUR III Trial)
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1942
Start Date
2024-03-13
Completion Date
2029-12-01
Last Updated
2025-02-24
Healthy Volunteers
No
Conditions
Interventions
Intravascular ultrasound-guided stent implantation after angiography-derived FFR-based decision-making
The percutaneous coronary intervention will be performed by intravascular ultrasound (IVUS)-guided strategy after angiography-derived FFR-based decision-making: 1. PCI will be performed if angiography-derived FFR ≤0.80 and will be deferred if angiography-derived FFR \>0.80. 2. If PCI is performed, PCI optimization using IVUS will be performed following the recommended criteria: ① Plaque burden at stent edge ≤55%; ② Minimal stent area ≥ 5.5 mm2, or minimal stent area ≥ distal reference lumen area
Fractional flow reserve-guided PCI strategy
The percutaneous coronary intervention will be performed by fractional flow reserve (FFR)-guided strategy: 1. PCI will be performed if FFR ≤0.80 and will be deferred if FFR \>0.80. 2. If PCI is performed, PCI optimization using FFR will be performed following the recommended criteria: ① Post-PCI FFR ≥ 0.88, or ② Post-PCI ΔFFR (\[FFR at stent distal edge\] - \[FFR at stent proximal edge\]) \< 0.05
Locations (25)
Peking University Third Hospital
Beijing, China
Second Affiliated Hospital of Shantou University Medical College
Guangdong, China
The Affiliated Hospital of Hangzhou Normal University
Hangzhou, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
Changxing People's Hospital
Huzhou, China
The Affiliated Hospital of Shandong University of TCM
Jinan, China
The Fourth People's Hospital of Jinan
Jinan, China
Jinhua Central Hospital
Jinhua, China
First Affiliated Hospital of Kunming Medical University
Kunming, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
Ningbo Medical Center Lihuili Hospital
Ningbo, China
The Affiliated Hospital of Medical College, Ningbo University
Ningbo, China
Renji Hospital Shanghai Jiaotong University School of Medicine
Shanghai, China
The First Affiliated hospital of Wenzhou Medical University
Wenzhou, China
Bucheon Sejong Hospital
Bucheon-si, South Korea
Inje University Haeundae Paik Hospital
Busan, South Korea
Keimyung University Dongsan Medical Center
Daegu, South Korea
Kyungpook National University Hospital
Daegu, South Korea
Chonnam National University Hospital
Donggu, South Korea
Inje University Ilsan Paik Hospital
Goyang, South Korea
Seoul National University Hospital,
Seoul, South Korea
Seoul ST. Mary's Hospital
Seoul, South Korea
Uijeongbu Eulji Medical Center
Uijeongbu-si, South Korea
Ulsan University Hospital
Ulsan, South Korea
Yonsei University Wonju Severance Hospital
Wŏnju, South Korea