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COMPLETED
NCT06218550
PHASE1

Delta-8-THC vs. Delta-9-THC on Simulated Driving Performance

Sponsor: Johns Hopkins University

View on ClinicalTrials.gov

Summary

Delta-8-THC is an isomer of delta-9-THC that has become widely available due to the legalization of hemp and its derivatives. Very little controlled research has been conducted with delta-8-THC and some research suggests it produces similar effects to delta-9-THC, albeit at lower potency. The present study will evaluate the dose effects of delta-8-THC, compared with delta-9-THC, on simulated driving performance, field sobriety tests, cognitive performance, and biomarkers of exposure to cannabinoids. The results will inform policy and education related to impairment due to acute delta-8-THC exposure via vaporization and oral ingestion.

Official title: The Effect of Delta-8-THC vs Delta-9-THC on Simulated Driving Performance and Measures of Impairment

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2024-07-01

Completion Date

2025-09-08

Last Updated

2026-07-20

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

Delta-9-THC

Acute self-administration of inhaled or oral ∆9-THC by healthy adult research volunteers

DRUG

Delta-8-THC

Acute self-administration of inhaled or oral ∆8-THC by healthy adult research volunteers

DRUG

Placebo

Consumption of a brownie or inhalation of ambient air through a cannabis vaporizer by health adult research volunteers

Locations (1)

Johns Hopkins Behavioral Pharmacology Research Unit

Baltimore, Maryland, United States