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Analysis of PD-L1, TMB, MSI and ctDNA Dynamics to Predict and Monitor Response to Immunotherapy in Metastatic Cancer.
Sponsor: Gene Solutions
Summary
This is an observational clinical trial, aiming to investigate whether the ctDNA dynamics could predict early response to ICIs in patients with advanced-stage cancer. Moreover, conventional tumor markers PD-L1, TMB and MSI are to be investigated for their combined prognostic values in ICI treatment.
Official title: Analysis of PD-L1, TMB, CTDNA in Immunotherapy Response Monitoring and Prediction in Advancer Lung Cancer Treatment.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2024-03-22
Completion Date
2026-12-31
Last Updated
2026-01-16
Healthy Volunteers
No
Conditions
Locations (2)
University of Medicine and Pharmacy at HCMC
Ho Chi Minh City, Hồ Chí Minh, Vietnam
Medical Genetics Institute
Ho Chi Minh City, Vietnam