Clinical Research Directory

Inclusion Criteria: * Biological Female which identify themselves as Women * Aged ≥ 40 years * Irregular menstrual cycle for at least 3 months * Presenting typical symptoms of perimenopause with GCS score over 20 * BMI range between 18-35 kg/m2 * Healthy woman Exclusion Criteria: * Less than 40 years old * Pregnant * Diagnosed with diseases related to reproductive system such as PCOS or endometriosis * Taking anti-depressant medication or sleeping pills * Taking hormonal replacement therapy (HRT) * Taking conventional drug treatment or dietary supplementation * Having medical history or medical/surgical event in the last 6 months, or has been treated for cancer or any other ongoing treatment for the past 3 months, * Current and/or past history of hyper/hypotension, CVD, diabetes, autoimmune diseases, musculoskeletal disorder or endocrine or immunocompromised or neurological or psychological disorders, * Being medicated for these conditions, * History of allergic reactions to saffron intake, * Decisionally challenged subjects or unable to comply to the study * Any conditions that could contraindicates the use of saffron * Currently smoking or ceased smoking in the past 3 months