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Effect of Diluent Volume on Colistin Inhalation Therapy
Sponsor: Fu Jen Catholic University
Summary
The aim of this study is to investigate the impact of different diluent volumes for the same dosage of colistin in mechanically ventilated respiratory patients receiving colistin inhalation therapy. The study aims to determine whether the diluent volume has an effect on clinical outcomes, including ICU length of stay, total hospitalization duration, duration of respiratory support within 28 days, mortality rates within 28 days and 90 days, as well as analyze the pharmacokinetic profile of colistin in blood and bronchoalveolar lavage fluid. Additionally, the study will evaluate the incidence of nebulizer malfunctions and blockages. The findings of this research will help identify the optimal diluent volume for colistin inhalation therapy in clinical practice.
Official title: Effect of Diluent Volume on Colistin Inhalation Therapy for Mechanically Ventilated Respiratory Patients
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-03-10
Completion Date
2026-07-31
Last Updated
2026-02-27
Healthy Volunteers
No
Conditions
Interventions
Colistin 1 MU in normal saline 1 ml
Colistin 1 MU diluted in normal saline 1 ml, total volume of 12 ml
Colistin 1 MU in normal saline 2 ml
Colistin 1 MU diluted in normal saline 2 ml, total volume of 12 ml
Locations (1)
Fu Jen Catholic University Hospital, Fu Jen Catholic University
New Taipei City, Taiwan