Clinical Research Directory
Browse clinical research sites, groups, and studies.
Paroxetine Safety and Efficacy in Rheumatoid Arthritis
Sponsor: Mostafa Bahaa
Summary
Rheumatoid arthritis (RA) is a systemic chronic auto-inflammatory disorder which imposes a remarkable burden of morbidity and mortality on global health. The complex interaction between genetics, environment, and immunological response contribute to RA pathogenesis. Current treatment comprises conventional disease-modifying anti-rheumatic drugs (DMARDs) followed by biological DMARDs, if necessary, to achieve low disease activity or remission. Therapeutics used in RA had limitations in tolerability, access, and response duration and magnitude. Consequently, implementation of safe adjunctive treatment for RA is urgently needed to boost the therapeutic response.
Official title: The GRK2 Inhibitor Paroxetine as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients.
Key Details
Gender
All
Age Range
23 Years - 57 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2024-01-31
Completion Date
2026-02-20
Last Updated
2025-04-08
Healthy Volunteers
No
Conditions
Interventions
Methotrexate
Methotrexate (MTX) is an anti-metabolite most commonly used in chemotherapy and immunosuppressant in auto-immune diseases. This activity describes the indications, action, and contraindications for Methotrexate as a valuable agent in treating a wide variety of diseases.
Paroxetine
Paroxetine is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It's often used to treat depression, and sometimes obsessive compulsive disorder (OCD), panic attacks, anxiety or post-traumatic stress disorder (PTSD).
Locations (1)
Mostafa Bahaa
Damietta, New Damietta, Egypt