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The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
Sponsor: King's College Hospital NHS Trust
Summary
Acute kidney injury (AKI) is a common complication of septic shock and together these conditions carry a high mortality risk. In septic patients who develop severe AKI renal cortical perfusion is deficient despite normal macrovascular organ blood flow. This intra-renal perfusion abnormality may be amenable to pharmacological manipulation, which may offer mechanistic insight into the pathophysiology of septic AKI. The aim of the current study is to investigate the effects of vasopressin and angiotensin II on renal microcirculatory perfusion in a cohort of patients with septic shock.
Official title: The Effect of Vasopressor Therapy on Renal Perfusion in Patients With Septic Shock - a Mechanistically Focussed Randomized Control Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2024-01-05
Completion Date
2026-07
Last Updated
2025-04-04
Healthy Volunteers
No
Conditions
Interventions
Angiotensin II
Angiotensin II infusion
Vasopressin
Vasopressin infusion
Norepinephrine
Standard care vasopressor therapy, norepinephrine infusion
Locations (1)
King's College Hospital
London, United Kingdom