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Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Sponsor: Emory University
Summary
Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions.
Key Details
Gender
All
Age Range
45 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2021-08-09
Completion Date
2026-07
Last Updated
2026-03-27
Healthy Volunteers
Yes
Conditions
Interventions
Levodopa
Participants will take levodopa in dosages prescribed by their care provider. Patients will be instructed to not take their regularly prescribed PD medications for 12 hours prior to the study assessment, as is typical for clinical evaluations in patients with PD. Participants will be tested in both levodopa-off (after 12 hours of not having medication) and levodopa-on states.
Clinical DBS Setting
Deep brain stimulation performed with the patients' optimized clinical setting.
Sham DBS
Deep brain stimulation performed with sham stimulation.
DBS Setting Maximizing Prefrontal Activation
Deep brain stimulation performed to maximize the activation of the prefrontal cortico-STN projections.
DBS Setting Minimizing Prefrontal Activation
Deep brain stimulation performed to minimize the activation of the prefrontal cortico-STN projections.
Locations (2)
Emory University Hospital
Atlanta, Georgia, United States
Emory Brain Health Center
Atlanta, Georgia, United States