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Paracetamol Effect on Prostaglandins and Blood Pressure
Sponsor: Charite University, Berlin, Germany
Summary
This research program aims to investigate the influence of paracetamol on blood pressure and the cyclooxygenase (COX) - prostaglandine (PG) pathway in patients with pain. Through an observational pilot study, we will use advanced LC/ESI-MS/MS methodology to analyze the COX-OG pathway in plasma and urine. The study will assess the effects of paracetamol compared to ibuprofen, considering different types of pain. The primary focus is to understand the changes in blood pressure and the COX-PG pathway upon initiation or discontinuation of paracetamol, with safety analysis as a secondary consideration.
Official title: Paracetamol Impact Study: Prostaglandin Synthesis and Blood Pressure Effects (PIS-PaB)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
72
Start Date
2025-03-01
Completion Date
2026-09-01
Last Updated
2025-02-26
Healthy Volunteers
No
Conditions
Interventions
routine clinical treatment of pain with paracetamol or ibuprofen
No intervention beside clinical routine management