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Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas
Sponsor: National Cancer Institute, Naples
Summary
This is a multicentric, retrospective, and prospective biomarker study.
Official title: Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas of the Anogenital Tract and of the Head-neck Region for the Development of Shared Therapeutic Strategies
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
170
Start Date
2023-09-25
Completion Date
2026-03
Last Updated
2025-07-29
Healthy Volunteers
No
Interventions
Multiparameter analysis of each sample
Retrospective and prospective samples will be collected and analyzed for the study of molecular and viral biomarkers. Simultaneously, fibroblastic tumor-associated cells (CAFs) will be isolated from prospective samples. Through co-cultivation with immortalized cell lines derived from anogenital and head-neck SCCs, these CAFs will enable the production of 3D organoids for use in experiments assessing the response to telomerase and deacetylase SIRT1 inhibitors, both in vitro and in preclinical models.
Locations (4)
Istituto Tumori IRCCS Giovanni Paolo II di Bari
Bari, Bari, Italy
Istituto Nazionale Tumori | "Fondazione Pascale"
Naples, Napoli, Italy
Università del Piemonte orientale
Novara, Novara, Italy
Azienda Ospedaliera Universitaria Pisana
Pisa, Pisa, Italy