Clinical Research Directory

Inclusion Criteria: 1. Able and willing to provide a written informed consent 2. Has histologically-confirmed squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma of the cervix； 3. Has locally advanced cervical cancer； 4. At least one measurable lesion ( RECIST version 1.1)； 5. Investigator assess it is suitable for concurrent chemoradiotherapy; 6. Has provided a tissue sample from tumor lesion; 7. Cooperative Oncology Group (ECOG) performance status of 0 or 1; 8. BMI≥18.5kg/m2； 9. Female participants of childbearing potential must agree to use highly effective contraception during the treatment period and for at least 7 months after the last dose of drug，Female participants' HCG must be negative within 3 days prior to enrollment and must be non-lactating. Exclusion Criteria: 1. Histopathologically confirmed small cell carcinoma (neuroendocrine) or mucinous adenocarcinoma of the cervix； 2. The presence of distant metastatic disease was confirmed by pathology or imaging; 3. has previously undergone hysterectomy (including subtotal hysterectomy) or plan to undergo hysterectomy for cervical cancer, or plan to adopt fertility preservation therapy; 4. In the investigator's judgment, there is a disease (such as severe diabetes, neurological or psychiatric illness, etc.) or any other condition that seriously endangers the subject's safety, confuses the study results, or interferes with the subject's ability to complete the study.