Clinical Research Directory

Inclusion Criteria: 1. Male 2. Age ≥ 40 years and ≤ 55 years 3. Body mass index (BMI) \> 20 and \< 25 kg/m2 4. Physical activity level should as a minimum include: Active commuting by biking a minimum of 10 km, four days per week or an equivalent amount of other physical activity four days per week. 5. Healthy (based on self-reporting, pre-study medical examination and biochemical screening) 6. Can adhere to two weeks of inactivity (refrain from running, cycling and all other exercise while reducing steps to max. 1500 pr. day) 7. Caucasian 8. No change in body weight \> 5 kg within the last 6 months 9. Eats breakfast and lunch daily 10. Does not follow specific dietary restrictions 11. No disliking of spaghetti bolognese 12. No diagnosis of psychiatric disorder or treatment with anti-depressant or anti-psychotic medication 13. No history of suicidal behavior or ideations. 14. No previous surgical treatment for obesity 15. No cardiovascular disease 16. No rheumatologic disease 17. No metabolic/endocrine disease 18. No liver disease (ASAT or ALAT \>2x upper normal range) 19. No other chronic disease 20. No elite sports 21. No frequent or chronic use of medications affecting bodyweight, physical performance, or inflammation (NSAIDS, DMARDS, corticosteroids) 22. No current infection 23. No history of cancer 24. No anemia (hematocrit \<33%) 25. No smoking 26. No participation in other research intervention studies Exclusion Criteria: 1. Clinical or biochemical signs of disease 2. HbA1c \> 39 mmol/mol 3. Unable to allocate the needed time to fulfill the intervention 4. Language barrier, mental incapacity, unwillingness, or inability to understand and be able to complete the interventions