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COMPLETED
NCT06242665
NA

You Are What You Eat: Food as a Risk Factor and a Treatment for Depression

Sponsor: University of Michigan

View on ClinicalTrials.gov

Summary

This study experimentally investigates 1) whether ultra processed food (UPF) intake contributes to depression by increasing low mood and poor sleep due to blood glucose fluctuations (which then increases the desire to consume more UPFs) and 2) to investigate the effectiveness of a 2-week meal-kit intervention that provides convenient and tasty minimally processed foods (MPF) to reduce depression. The following aims and hypotheses are tested: Aim 1: To investigate whether UPF intake and low mood contribute to each other in a cyclical fashion through the mechanisms of blood glucose fluctuations and disrupted sleep in individuals with moderate-to-severe depression. H1: It is hypothesized that UPF intake and high blood glucose will be associated with low mood in individuals with depression. Aim 2: To establish an industry partnership to investigate whether commercially available meal kit delivery reduces symptoms of depression in individuals with moderate-to-severe depression relative to a nutrition education control condition. H2: Meal kit delivery will lead to reductions in depression symptoms and daily reductions in low mood relative to the control condition (nutrition guidance only).

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

47

Start Date

2023-12-09

Completion Date

2025-01-22

Last Updated

2026-07-20

Healthy Volunteers

No

Conditions

Interventions

OTHER

Low UPF Meals (Study Provided)

Meals provided through delivery service

OTHER

Low UPF Nutritional Guidance

Self-guided instructions from study team.

OTHER

Low UPF Snacks (Study Provided)

Low UPF snacks provided to participant

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States