Clinical Research Directory

Inclusion Criteria: * A written informed consent should be signed by a subject or his/her legal representative before any study-related procedures are performed; * 18 Years and older; * Subjects with histologically or cytologically confirmed locally advanced or metastatic advanced solid tumors; * Subjects must have at least one measurable lesion as defined by RECIST v1.1; * Eastern Cooperative Oncology Group(ECOG) performance status 0-1; * Expected survival ≥ 3 months; * Patients are willing to use a highly effective method of birth control during the study, and for at least 180 days after the last dose of study medication. Exclusion Criteria: * Patients who have received major surgical or interventional treatment within 4 weeks prior to the first dose, with the exception of tumor biopsy, puncture, etc. Patients who have received anti-tumor therapy (radiotherapy, immunologic therapy or biological therapy) within 4 weeks, prior to the first dose, or received small molecular targeted therapy, chemotherapy within 2 weeks, or received palliative radiotherapy for bone metastases within 2 weeks, or received nitrosoureas or mitomycin C within 6 weeks; * Patients who have received live vaccines within 4 weeks prior to the first dose; * Patients who have previously participated in clinical trials of other drugs within 4 weeks before the first dose; * Patients with a history of central nervous system disease within 12 months prior to enrollment, such as seizures, cerebral vascular embolism/hemorrhage, paralysis, aphasia, severe brain injury, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome, psychiatric disease, or any autoimmune disease with involvement of the central nervous system; * Presence of severe pulmonary diseases such as pulmonary embolism, interstitial lung disease at screening; * Patients who have previously received allogeneic tissue/solid organ transplantation; * Patients with active infection; * Patients who are positive for human immunodeficiency virus (HIV) (HIV1/2 antibody), positive treponema pallidum antibody (positive treponema pallidum antibody is required to undergo a confirmatory test, and those with negative confirmatory test can be enrolled), active chronic hepatitis B (HBsAg positive and HBV DNA \> 500 IU/mL) or active hepatitis C (HCV antibody positive and HCV-RNA \> lower limit of detection by the research center); * Female subjects who are lactating or have a positive blood/urine pregnancy result during the screening period; * Any other condition of the subject (e.g., mental, geographical, or medical condition) that does not allow him or her to comply with the study and follow-up procedures, or other conditions that, in the judgment of the investigator, the subject is not suitable for inclusion in this study.