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RECRUITING
NCT06249269

Reversal of Atrial Substrate to Prevent Atrial Fibrillation Cohort Study

Sponsor: Ratika Parkash

View on ClinicalTrials.gov

Summary

Atrial fibrillation (AF) is a major health problem, with a prevalence of 0.4-1% of the population. It results in high healthcare costs and significant morbidity, especially for patients with severe symptoms. The RASTA-AF randomized control trial (RCT) is designed to answer the following question: does vigorous treatment of AF with aggressive risk factor management plus catheter ablation reduce AF-related outcomes as compared to catheter ablation plus usual care in patients with symptomatic AF and risk factors that promote AF. This study is a multicenter, prospective cohort study that will enrol patients who decline participation in the RASTA-AF RCT but agree to be followed in a registry. The objective of RASTA-Cohort is to determine whether patients who decline participation in the RASTA-AF RCT have different clinical characteristics and quality of life than patients who accept participation in the study, and whether they suffer from worse AF-related outcomes than patients in the RCT.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

198

Start Date

2024-05-01

Completion Date

2027-03

Last Updated

2025-12-02

Healthy Volunteers

Not specified

Locations (7)

Foothills Hospital

Calgary, Alberta, Canada

QEIIHSC

Halifax, Nova Scotia, Canada

London Health Sciences Centre

London, Ontario, Canada

University of Ottawa Heart Institute

Ottawa, Ontario, Canada

Sunnybrook Hospital

Toronto, Ontario, Canada

Montreal Heart Institute

Montreal, Quebec, Canada

Regina General Hospital

Regina, Saskatchewan, Canada