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Diet-Induced Changes in GEnetic Material
Sponsor: Pennington Biomedical Research Center
Summary
This is a pilot study in 10 men to test the hypothesis that perturbations in substrate flux and the circulating metabolic and pro-inflammatory milieus during a high-fat diet paradigm will modulate DNA methylation of genes in sperm associated with obesity and cardiometabolic dysfunction.
Official title: A Pilot Study to Examine Metabolic Flexibility as a Mechanism for Diet- Induced Epigenetic Alterations in Male Gametes
Key Details
Gender
MALE
Age Range
20 Years - 35 Years
Study Type
OBSERVATIONAL
Enrollment
10
Start Date
2023-11-11
Completion Date
2026-12-30
Last Updated
2025-05-31
Healthy Volunteers
Yes
Locations (1)
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States