Clinical Research Directory

Inclusion Criteria: 1. Differential diagnosis which includes infection 2. Change in the quick Sequential Organ Failure Assessment (qSOFA) ≥2 or National Early Warning Score 2 (NEWS2) score ≥5 3. Aged ≥18 years Exclusion Criteria: 1. Traumatic injury 2. Rockwood frailty score ≥6 3. Critical care therapy previously believed to not be in patient's best interests 4. Critical care therapies-initiated pre-hospital. Critical care therapies defined as: 4.1 Mechanical ventilation 4.2 Vasopressor/inotrope therapy 4.3 Sedation or a general anaesthetic 4.4 Pre-hospital transfusion of blood products 4.5 Extra-corporeal support 5. Advanced directive refusing critical care therapies. 6. Acute cardiac failure 7. Active gastrointestinal bleed 8. Massive pulmonary embolism 9. ICU admission declined by critical care team 10. Treated in an acute hospital \<6 hours before presentation to the Emergency Department